Clinical Applications of Cytokines and Growth Factors

  • John R. Wingard, George D. Demetri
€ 271,41
5% studentenkorting Bestel twee verschillende Nederlandstalige boeken en krijg 5% studentenkorting
Bekijk online exemplaar
The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.
List of Contributors. Introduction. I. Biology of Hematopoietic and Lymphopoietic Cytokines. II. Management of Neutropenia and Neutropenic Fever. III. Management of Anemia. IV. Management of Thrombocytopenia. V. The Role of Cytokines to Enhance Cancer Chemotherapy. VI. Management of Marrow Failure States. VII. The Use of Cytokines in Blood and Marrow Transplantation. Index.
Uitgavejaar 1999
ISBN 9780792384861
Serie Developments in Oncology
Verschijningsdatum 31 mei 1999
Omvang 407
Redactie John R. Wingard, George D. Demetri
Editie 1999 ed.
Auteur(s) John R. Wingard George D. Demetri
Reeksnummer 80
Bindwijze Gebonden
Taal Engels
Uit dezelfde reeks
€ 282,31
Molecular Genetics of Colorectal Neoplasia James M. Church Graham Casey
€ 152,59
Hemostatic Mechanisms and Metastasis Kenneth V. Honn Bonnie F. Sloane
€ 271,41
Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development Frederick A. Valeriote Thomas H. Corbett Laurence H. Baker
€ 336,81
Minimal Residual Disease in Acute Leukemia B. Loewenberg A. Hagenbeek
€ 94,82
€ 249,61
Gerelateerde producten
Kumar and Clark's Clinical Medicine Adam Feather David Randall Mona Waterhouse
Speciale prijs € 60,99 Normale prijs € 74,00
Medical Statistics at a Glance Aviva Petrie Caroline Sabin
Speciale prijs € 30,99 Normale prijs € 33,80
€ 59,95
Textbook of Immunopsychiatry Golam Khandaker Neil Harrison Edward Bullmore
€ 58,34

Scroll to top