Ibuprofen: Pharmacology, Therapeutics and Side Effects

  • K. D. Rainsford
€ 196,19
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Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Introduction.- Biodisposition in relation to actions.- Mechanisms of inflammation and sites of action of NSAIDs.- Clinical efficacy.- Drug derivatives and formulations.- General safety profile.- Gastro-intestinal toxicity.- Cardiovascular safety.- Renal toxicity.- Hepatic toxicity.- Other adverse reactions.- Global assessment of adverse reactions & human toxicology.- Overall assessment.
From the reviews: "This book is intended for a broad readership -- anyone interested in the properties, actions, and uses of ibuprofen. This book serves this aim very well ... . The book is of great value for anyone who wants to understand the historical development and clinical utility of a very popular nonsteroidal anti-inflammatory drug (NSAID) ... . This is an outstanding historical and factual account of ibuprofen, one of the most widely used analgesic/antipyretic/anti-inflammatory drugs today." (Thomas L. Pazdernik, Doody's Book Reviews, May, 2013)
Uitgavejaar 2013
ISBN 9783034804950
Verschijningsdatum 31 jan. 2013
Omvang 243
Editie 2012 ed.
Auteur(s) K. D. Rainsford
Bindwijze Gebonden
Taal Engels
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