This vibrant collection delivers a laboratory roadmap of testing cognition in the rodent. While rodents and mazes are the main center and focus of this book, many aspects in the field of learning and memory are discussed and detailed, spanning from the molecular to the human, with every chapter delivering a comprehensive review of historical milestones in order to provide context for past discoveries, new findings, and future studies. Didactic foundations, operational definitions, and theory, as well as practical experimental and apparatus set-up, data analysis, and interpretation instructions are included in the first part of the book, while part two contains step-by-step protocols, troubleshooting, and tips from experts in the field.Authoritative and inspirational, The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition serves as a detailed and practical manual for scientists wishing to implement these tools in their laboratories and for scholars interested in this powerful field.
Part I: Why? Foundations of Rodent Learning and Memory: Milestones, Mazes, and Mechanisms 1. Rodent Mazes and Memory: Continuing the Search for the Engram Heather A. Bimonte-Nelson 2. The Mazes Heather A. Bimonte-Nelson, Jill M. Daniel, and Stephanie Koebele 3. The Watermaze Richard G.M. Morris 4. Behavioral Consequences of Early Disruption and Injury to the Developing Brain: Studying Rodent Models Dongnhu T. Truong and R. Holly Fitch 5. Insights into Age-Related Cognitive Decline: Coupling Neurophysiological and Behavioral Approaches Lesley A. Schimanski and Carol A. Barnes 6. Organization and Structure of Brain Systems Supporting Memory Jena B. Hales and Robert E. Clark 7. Pharmacologically Manipulating Learning and Memory Ashley M. Fortress and Karyn M. Frick 8. Stress and Spatial Maze Performance in the Rat Sara B. Taylor, Cheryl D. Conrad, and M. Foster Olive 9. Genetically Modified Rodent Models: A New Generation of Translational Cognitive Science Salvatore Oddo and Masashi Kitazawa 10. Epigenetics of Cognition and Neurodegenerative Disorders Paul Coleman, Matthew Huentelman, and Travis Dunckley 11. The Importance of Incorporating Both Sexes and Embracing Hormonal Diversity When Conducting Rodent Behavioral Assays Sarah E. Mennenga and Heather A. Bimonte-Nelson 12. A Primer of Methods in Biobehavioral Research: Improving a Study's Design, Analysis, and Write Up Joshua S. Talboom, Stephen G. West, and Heather A. Bimonte-Nelson 13. Optimal Guidelines for Monitoring and Maintaining Rodent Health for Behavioral Research: What's Right with My Rodent? Joanne Tetens-Woodring Part II: How? The Mazes: Protocols and Practice to Test Rodent Cognition 14. General Water-Escape Maze Testing Necessities and Guidelines for Rodents Heather A. Bimonte-Nelson 15. Water Radial-Arm Maze: 4 out of 8 Arms Platformed Protocol for Rodents Heather A. Bimonte-Nelson 16. Water Radial-Arm Maze: 7 Out of 8 Arms Platformed Protocol for Rodents Heather A. Bimonte-Nelson 17. Land Radial-Arm Maze: 8 Out of 8 Arms Baited with Food Protocol for Rodents Jill M. Daniel 18. Delayed Match to Sample Protocol for Rodents Heather A. Bimonte-Nelson 19. Morris Maze Protocol for Rodents Heather A. Bimonte-Nelson 20. The Visible Platform Protocol for Rodents Heather A. Bimonte-Nelson