Nuclear Medicine in Clinical Oncology

I. Introduction and Basic Considerations.- Nuclear Oncology: Current Role and Future Direction.- Nuclear Principles of Tumor Detection.- Mechanisms Responsible for Radioactive Tracer Uptake in Malignancies.- II. Technical Principles.- Gamma Camera Imaging and Single Probe Detection of Tumors.- Single Photon and Positron Emission Computerized Tomography in Tumor Diagnosis.- NMR Tomography of Cancer: Technical Considerations.- Parameter-Selective Proton NMR Imaging and Tissue Characterization In Vivo.- Development of Magnetic Resonance Contrast Media for Tumors.- Computer-Assisted Echographic Tissue Characterization in Tumor Diagnostics.- III. Diagnostic Use of Radiopharmaceuticals.- Clinical Aspects of Detection and Imaging of Brain Tumors.- Noncontact Eye Tumor Imaging with a Gamma Camera.- Clinical Aspects of Detection and Imaging of Differentiated Thyroid Tumors.- Clinical Aspects of Detection and Imaging of Lung Tumors.- Clinical Aspects of Detection and Imaging of Tumors of Liver and Spleen.- Use of Scintigraphy for Evaluation of Patients with Renal Malignancies.- Scintigraphy of Lymphokinetics and Lymphatic Neoplasia.- Bone Scintigraphy in Primary Malignant Bone Tumor.- Scintigraphic Detection of Bone Metastases.- Metaiodobenzylguanidine in the Diagnosis of Neuroblastomas.- Scintigraphic Imaging of Pheochromocytomas by Means of Metaiodobenzylguanidine (MIBG).- Nuclear Medicine in the Diagnosis of Skin Tumors.- IV. Radioimmunodetection.- Principles of Radioimmunodetection of Tumors.- Immunoscintigraphy of CEA-Producing Tumors with Special Emphasis on the Use of Mab Fragments and ECT.- Beta-hCG and Related Germ Cell Tumor Antigens in Radioimmunodetection.- Radioimmunodetection with Monoclonal Antibodies Against Prostatic Acid Phosphatase.- Immunoscintigraphy of Ovarian Cancer by Means of HMFG2 Monoclonal Antibody.- Immunoscintigraphy of Gynaecological Tumors.- Radioimmunoscintigraphy by Means of Melanoma Antibody.- Radioimmunoscintigraphy of CA 19-9/CEA Producing Tumors Using I-131 Labeled F (ab?)2 Fragments of Monoclonal Antibodies (19-9/Anti-CEA Radioimmunococktail).- Radioimmunodetection of Malignant Melanoma with Radiolabelled (131I, 123I, 111In, 99mTc) Monoclonal Antibodies and F (ab?)2 Fragments.- Imaging of Bone and Soft Tissue Tumors Using an Antitumor Monoclonal Antibody.- V. Nuclear Magnetic Resonance Imaging and In Vivo Spectroscopy.- Current Status of Magnetic Resonance Imaging of the Central Nervous System.- NMR Imaging of Tumors in the Body Stem.- NMR In Vivo Spectroscopy in Tumor Diagnosis.- VI. Positron Emission Tomography.- Production and Use of Positron-Emitting Test Substances for Tumor Diagnosis.- Uptake of 11C-Aminocyclopentane Carboxylic Acid (ACPC) and 13N-Ammonia in Malignant Tumors. A Comparative Clinical Study.- Analysis of Brain Tumor Physiology by Positron Emission Tomography.- VII. Use of Tumor Markers In Vitro.- Overview of the Development of Tumor Markers.- The Clinical Value of Tumor-Associated Proteins in Gastrointestinal Cancer.- The Value of Tumor Markers in the Diagnosis of Urogenital Carcinoma.- Tumor Markers for Monitoring Therapy in Lung Cancer.- Tumor Markers for Follow-Up of Thyroid Carcinoma.- Use of Tumor Markers for Patient Monitoring in Breast Cancer.- Tumor Markers for Monitoring Breast Cancer Patients.- VIII. Therapeutic Use of Radiopharmaceuticals Including Labelled Antibodies.- Radioiodine Treatment of Thyroid Carcinomas.- Therapy of the Neuroblastoma with 131I-MIBG.- Treatment of Pheochromocytomas with 131I-Metaiodobenzylguanidine.- Treatment of Neuroblastoma by 131I-Metaiodobenzylguanidine (131I-MIBG): Qualitative and Quantitative Scintigraphic Evaluation of the Treatment Effect.- Endolymphatic Radionuclide Therapy (ELRT) in Malignant Melanoma of the Lower Extremities.- On the Efficacy of Strontium-89 Therapy. Preliminary Evaluation of a Double-blind Study.- Cancer Treatment with Radioactive Labeled Antibodies.- Treatment of Pleural and Peritoneal Carcinosis with Radioactive Colloids.- Treatment of Hepatic Malignancies by Intravascular Administration of Radioisotopes.- Treatment of Local Prostatic Cancer by 125Iodine Seeds.- CT-Guided Stereotactic Implantation with Iridium-192 and Iodine-125 of Non-Resectable Intracranial Tumors.- IX. Experimental Approaches and Future Aspects.- Radioimmunodetection of Hodgkin Tumors in Nude Mice.- Immunoscintigraphy of Human Pancreatic Carcinoma in Nude Mice with F(ab?)2 Fragments of Monoclonal Antibodies to CA 19-9 and CEA.- Physico-chemical Properties and Biokinetics of Tumor-Affine Metal (M)-Ligand-Complexes.- Iodoazomycin Riboside [1-(5?-iodo-5?-deoxyribofuranosyl)-2-nitroimidazole],a Hypoxic Cell Marker. In Vivo Evaluation in Experimental Tumors].- The Potential Use of Alpha and Auger-Electron Emitting Radionuclides for Therapy.- Studies on the In Vivo Stability of 211At Labelled Albumin Particles in Mice.